DDAH2 — Dimethylarginine dimethylaminohydrolase 2
DDAH2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDAH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Membrane adhesion remodeling migration & adhesion | ARL6IP5, ATP6V0E1, CAMK1D, CAST, CELF2, EMP3, FLNA, FXYD5 +6 more | View in SCUBA |
| Endothelial | Endothelial NO Activation Endothelial cell development | BCL6B, BLOC1S1, CD99, CDH13, COX5A, CREM, DDX46, EEA1 +8 more | View in SCUBA |
| Fibroblasts | Elastin-Fibronectin ECM ECM production | ABI3BP, ELN, FN1, LRIG3, S100A4, SERPINE2, SOD3, SSC5D | View in SCUBA |
| Glial cells | Glial Identity Homeostasis Housekeeping | ARPC1B, CMTM5, CPQ, FCGRT, METRN, PON2, S100B, SLC22A17 +2 more | View in SCUBA |
| Goblet cells | Epithelial Maintenance Housekeeping | COX7A2L, IP6K2, LAPTM4A, MARCKS, METTL9, MKRN1, RNF44 | View in SCUBA |
About the gene
| Synonyms | G6A |
|---|---|
| Chromosome | 6: 31727038-31730617 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS. In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.