PON2 — Paraoxonase 2
PON2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PON2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Proteasomal Degradation Protein processing & ER | GNL3, HACD3, MRPL36, NME4, NUDT5, PSMA1, PSMB5, PSMC1 +3 more | View in SCUBA |
| Glial cells | Glial Identity Homeostasis Housekeeping | ARPC1B, CMTM5, CPQ, DDAH2, FCGRT, METRN, S100B, SLC22A17 +2 more | View in SCUBA |
| Lymphatic endothelial | Innate Immune Activation Immune regulation | CD46, CLTC, CRIM1, EIF2AK2, ENSA, FEZ2, GSN, PDLIM3 +9 more | View in SCUBA |
| Macrophages | Fc Receptor Phagocytosis Lysosomal & pahgocytosis | ANXA6, C1orf162, CD37, FCGR1A, FCGR3A, FPR1, GCA, HNMT +10 more | View in SCUBA |
About the gene
| Chromosome | 7: 95404862-95435329 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase |
Function
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.