Glial Identity Homeostasis
Gene co-expression module in Glial cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
METRN (meteorin) is a secreted glial factor that promotes glial differentiation and neuroprotection. S100B is a canonical enteric glial marker. FCGRT (neonatal Fc receptor) mediates IgG transcytosis and is expressed in glia. PON2 is an antioxidant lactonase expressed in glial cells. DDAH2 regulates nitric oxide via ADMA metabolism. ARPC1B mediates actin branching for morphological maintenance. CMTM5 and SYPL1 are membrane proteins enriched in glial/neural tissue. Core coherence and uniform expression support a glial homeostatic identity program; suppression in inflammation and recovery in remission is consistent with glial quiescence programs.
Genes
ARPC1B, CMTM5, CPQ, DDAH2, FCGRT, METRN, PON2, S100B, SLC22A17, SMIM5, SYPL1
Most correlated modules
- Glial Cytoskeletal Homeostasis · correlation 0.89
- Enteric Glial Identity · correlation 0.86
- Lysosomal Sphingolipid Metabolism · correlation 0.86
- Glial Myelination Identity · correlation 0.85
- Basement Membrane Adhesion · correlation 0.81
- Glutathione Detoxification · correlation 0.78
- Antioxidant Stress Response · correlation 0.78
- Matricellular ECM Homeostasis · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.