SLC5A11 — Solute carrier family 5 member 11
SLC5A11 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC5A11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Colonocyte Solute Transport Absorption | ACSS1, ASPA, DAB1, DNASE1, MAOB, SFXN1, SLC26A2, SLC5A12 +1 more | View in SCUBA |
About the gene
| Synonyms | KST1, SGLT6, SMIT2 |
|---|---|
| Chromosome | 16: 24845841-24911628 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Apoptosis, Ion transport, Sodium transport, Sugar transport, Symport, Transport |
Function
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro- inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.