ACSS1 — Acyl-CoA synthetase short chain family member 1
ACSS1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACSS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Colonocyte Solute Transport Absorption | ASPA, DAB1, DNASE1, MAOB, SFXN1, SLC26A2, SLC5A11, SLC5A12 +1 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACADVL, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8, CRELD2 +20 more |
About the gene
| Synonyms | ACAS2L, AceCS2L, dJ568C11.3, MGC33843 |
|---|---|
| Chromosome | 20: 25006230-25058980 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Ligase |
| Biological process | Lipid metabolism |
Function
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.