MAOB — Monoamine oxidase B
MAOB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAOB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Colonocyte Solute Transport Absorption | ACSS1, ASPA, DAB1, DNASE1, SFXN1, SLC26A2, SLC5A11, SLC5A12 +1 more | View in SCUBA |
| Fibroblasts | Neural-crest Fibroblast Developmental | AMIGO2, C1orf54, CENPW, DCLK1, FLRT2, FOXP2, IGFBP4, KIAA0408 +8 more | View in SCUBA |
| Smooth muscle cells | Stromal Chemokine Secretion Inflammation | C7, CCL19, CCL2, CCL21, CH25H, CXCL12, CXCL2, LINC00924 +9 more | View in SCUBA |
About the gene
| Chromosome | X: 43766610-43882450 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
Function
Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.