ASPA — Aspartoacylase
ASPA belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Colonocyte Solute Transport Absorption | ACSS1, DAB1, DNASE1, MAOB, SFXN1, SLC26A2, SLC5A11, SLC5A12 +1 more | View in SCUBA |
| Fibroblasts | Elastic Fiber ECM ECM production | ADD3, FBLN5, FRMD3, PLTP, SLC29A1, SLIT2, SVEP1, TNXB | View in SCUBA |
About the gene
| Synonyms | ACY2, ASP |
|---|---|
| Chromosome | 17: 3472374-3503405 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.