SMARCD2 — SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMARCD2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMARCD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Glycosylation & trafficking Protein processing & ER | AASDHPPT, ABHD12, ACTR1A, ANKRD35, AP1S1, ARRDC1, ATF6B, ATG5 +25 more | View in SCUBA |
| Gamma-delta T cells | RNA Processing RNA processing & translation | ATP5F1A, ATP5F1B, ATP5F1C, ATP5IF1, BUD23, CIAO2B, E2F4, ELAVL1 +12 more | |
| Macrophages | Retromer Endosomal Sorting Vesicular traficking | ABHD15, ARHGAP45, ARHGAP9, CNPY3, CRBN, CTSO, DAB2, DRAM2 +20 more | View in SCUBA |
About the gene
| Synonyms | BAF60B, CRACD2, PRO2451, Rsc6p |
|---|---|
| Chromosome | 17: 63832081-63843065 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | Transcription, Transcription regulation |
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.