ELAVL1 — ELAV like RNA binding protein 1
ELAVL1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ELAVL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitochondrial Metabolism Mitochondrial & OxPhos | CYC1, HINT2, PRDX3, RNPS1, SHMT2, SNRPA, TEX30, ZWILCH | View in SCUBA |
| Gamma-delta T cells | RNA Processing RNA processing & translation | ATP5F1A, ATP5F1B, ATP5F1C, ATP5IF1, BUD23, CIAO2B, E2F4, FAM50A +12 more | |
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ALOX5AP, CNOT7, COMMD10, FKBP8, FNTA, IFI27L2, IL32, LPXN +11 more | View in SCUBA |
| Macrophages | ER Morphology Stress Stress | ARMC1, ARPP19, ATL3, CMPK1, CYB5B, EIF2AK1, ERGIC2, HDAC2 +8 more | View in SCUBA |
About the gene
| Synonyms | Hua, HUR, MelG |
|---|---|
| Chromosome | 19: 7958573-8005659 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
Function
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.