RNA Processing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes span two programs: RNA processing (RTRAF - RNA transcription factor, PABPN1 - poly(A) binding protein nuclear 1, INTS11 - integrator complex endonuclease, LSM8 - RNA splicing Sm-like protein, ELAVL1 - HuR RNA binding protein, E2F4 - transcription factor, BUD23 - rRNA methyltransferase) and ATP synthase (ATP5F1A, ATP5F1B, ATP5F1C - F1 catalytic subunits, ATP5IF1 - inhibitory factor). SELENOT and SELENOS (selenoproteins) support ER/redox housekeeping. MRPL57 (mitochondrial ribosome) bridges both programs. Given the neighborhood context (ATP synthase-heavy modules M9, M103), the ATP synthase and RNA processing co-expression here likely reflects co-regulated housekeeping transcription. The dominant hub (RTRAF) and multiple RNA processing genes make RNA processing the primary label.
Genes
ATP5F1A, ATP5F1B, ATP5F1C, ATP5IF1, BUD23, CIAO2B, E2F4, ELAVL1, FAM50A, INTS11, LSM8, MMP24OS, MRPL57, NDUFAF8, NENF, PABPN1, RAC1, RTRAF, SELENOS, SELENOT, SMARCD2
Most correlated modules
- ATP Synthase Complex · correlation 0.86
- RNA Splicing Processing · correlation 0.81
- Mitochondrial Biogenesis · correlation 0.78
- ER Protein Biogenesis · correlation 0.76
- Electron Transport Chain · correlation 0.74
- TCR Vesicular Trafficking · correlation 0.73
- snRNP Splicing · correlation 0.73
- Chromatin Architecture · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.