ARHGAP9 — Rho GTPase activating protein 9
ARHGAP9 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Activation Stress Response Stress | ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES, HMGCR +12 more | |
| Innate lymphoid cells | JAK-STAT Cytokine Signaling Inflammation | AASDHPPT, CHURC1, CIDEB, CSK, DCAF7, DENND2D, EDEM2, EIF4EBP2 +23 more | View in SCUBA |
| Macrophages | Retromer Endosomal Sorting Vesicular traficking | ABHD15, ARHGAP45, CNPY3, CRBN, CTSO, DAB2, DRAM2, FAM217B +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Splicing Regulation RNA processing & translation | AREG, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R, NEU1 +9 more | |
| Natural Killer cells | NK/ILC Differentiation Differentiation | CHKA, CHPT1, PIM2, PITPNC1, PPP1R16B, STAM, ZBTB16 | View in SCUBA |
About the gene
| Synonyms | 10C, MGC1295 |
|---|---|
| Chromosome | 12: 57472264-57488814 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5- bisphosphate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.