Retromer Endosomal Sorting
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 29 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 29 genes have a known function matching the annotation |
Why this annotation
SNX2, SNX5, and SNX6 are core retromer-associated sorting nexins that form the SNX-BAR dimer complex mediating endosome-to-Golgi retrieval. CNPY3 is an ER chaperone for TLR folding. GRK2 phosphorylates GPCRs for endocytosis. ARHGAP9 regulates Rho GTPases at endosomes. NAGA and CTSO are lysosomal hydrolases. IFI16 is an innate immune sensor. The SNX2/5/6 triad strongly anchors this module to retromer-mediated endosomal sorting.
Genes
ABHD15, ARHGAP45, ARHGAP9, CNPY3, CRBN, CTSO, DAB2, DRAM2, FAM217B, GDE1, GLIPR1, GRK2, IFI16, INAFM2, KCNE3, LAT2, NAGA, NELFB, NIPSNAP2, NSL1, PKN1, QARS1, RABL6, RNF135, SMARCD2, SNX2, SNX5, SNX6, TECR
Most correlated modules
- TGF-beta Signaling · correlation 0.96
- Endosomal Membrane Trafficking · correlation 0.95
- Nuclear Pore Transport · correlation 0.95
- ER Protein Quality Control · correlation 0.95
- Lysosomal Hydrolase Program · correlation 0.94
- Myeloid Innate Signaling · correlation 0.94
- Innate Antiviral Sensing · correlation 0.93
- Macrophage Proliferation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.