CNPY3 — Canopy FGF signaling regulator 3
CNPY3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CNPY3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lysosomal proteases Protein processing & ER | CD63, CD82, CTSA, CTSC, CTSD, CTSZ, FUT8, GALNT1 +2 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, DBNL, ENG, IL16, LIMD2, LSM2, MAPKAPK3, PHYKPL +11 more | View in SCUBA |
| Macrophages | Retromer Endosomal Sorting Vesicular traficking | ABHD15, ARHGAP45, ARHGAP9, CRBN, CTSO, DAB2, DRAM2, FAM217B +20 more | View in SCUBA |
About the gene
| Synonyms | CAG4A, TNRC5 |
|---|---|
| Chromosome | 6: 42929480-42939294 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Immunity, Innate immunity |
Function
Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.