SRF — Serum response factor
SRF belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SRF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Chromatin Transcriptional Control chromatin regulation & transcription | ARIH1, DSP, FGFBP1, KDM6B, KHDC4, KIAA0040, MNT, PABPN1 +6 more | View in SCUBA |
About the gene
| Synonyms | MCM1 |
|---|---|
| Chromosome | 6: 43171269-43181506 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.