KDM6B — Lysine demethylase 6B

KDM6B belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KDM6B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, CD83, DUSP1, EIF1, FOS, FOSB, JUN +7 more	View in SCUBA
CD4⁺ T cells	TCR early activation TCR/AP1/NFKb pathway	ARIH1, BRAF, CCNT1, CLEC2D, ELL2, EMD, FAM133B, FOSL2 +11 more	View in SCUBA
Endothelial	Integrated Stress Response Stress	ARL5B, ATF3, CCNL1, CD83, CDKN1A, DDIT3, ICAM4, IRF1 +3 more	View in SCUBA
Fibroblasts	NF-κB Epigenetic Reprogramming Inflammatory	BCL3, BTG2, CDKN1A, CSRNP1, DUSP5, EGR2, KLF10, LDLR +3 more	View in SCUBA
Gamma-delta T cells	NF-κB Activation Inflammation	DUSP5, GADD45A, HERPUD1, IL21R, MAFF, NAMPT, NFKB1, NFKB2 +13 more
Goblet cells	Stress Chromatin Remodeling chromatin regulation & transcription	ETS2, GADD45A, PMAIP1, SDC4, SOX9, YBX3, ZBTB7A, ZFAND5 +1 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	AHI1, CD83, FAM107B, FKBP2, GADD45A, HES4, MRPS36, PRPF4B +7 more	View in SCUBA
Lymphatic endothelial	NF-κB Inflammatory Activation Inflammation	BCL3, CD83, HIF1A, INSIG1, IPO7, IRF1, MAP3K8, NFKBIZ +1 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Monocytes	Epigenetic Inflammatory Reprogramming Inflammatory	BHLHE40, EHD1, PHACTR1, PLEK, PPIF, SMAD7, SOD2, ZNF267	View in SCUBA
Mucosal-associated invariant T cell	Stress-Induced Growth Arrest Stress	CDKN1A, GNA15, KLF10, MMP9, MYADM, NOCT, NR4A3, PLK3 +8 more
Natural Killer cells	NF-κB Activation Inflammation	ARL5B, BIRC3, CD83, NFKBID, NR4A1, NR4A3, RASGEF1B, REL	View in SCUBA
Neutrophils	Inflammatory Resolution Stress	ARL5B, ATG2A, ATP2B1, BTG1, CREM, DDIT4, FOSL2, GPR65 +4 more

About the gene

Synonyms	JMJD3, KIAA0346
Chromosome	17: 7834217-7854796
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Molecular function	Chromatin regulator, Dioxygenase, Oxidoreductase
Biological process	Inflammatory response

Function

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4- containing SWI/SNF remodeling complex (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.