Chromatin Transcriptional Control
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
MNT is a MAX-network transcriptional repressor antagonizing MYC targets. KDM6B is a histone H3K27 demethylase that activates gene expression by removing repressive marks, critical for inflammatory and differentiation gene programs. SRF (serum response factor) drives immediate-early and cytoskeletal gene transcription. ZBTB21 and ZNF587 are additional transcription factors. ARIH1 is an E3 ubiquitin ligase regulating transcription factor stability. TNFRSF10B (DR5/TRAIL-R2) and PHLDA2 add an apoptotic/stress-response component. DSP (desmoplakin) reflects epithelial integrity. Strong coherence supports a unified chromatin/transcriptional regulatory program. Positive remission_UC delta suggests restoration of normal transcriptional control.
Genes
Most correlated modules
- Splicing Regulation · correlation 0.90
- GPCR Peptide Signaling · correlation 0.89
- Chromatin-Coupled Splicing · correlation 0.84
- Dissociation Stress Artifact · correlation 0.79
- Actin Cytoskeletal Regulation · correlation 0.77
- Focal Adhesion Migration · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.