SUSD4 — Sushi domain containing 4
SUSD4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SUSD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proliferation/differentiation Cell cycle | AIG1, AKAP7, CCND1, DTX1, KLF4, TLR5, ZNF827 | View in SCUBA |
About the gene
| Synonyms | FLJ10052 |
|---|---|
| Chromosome | 1: 223220819-223364233 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Complement pathway, Immunity, Innate immunity |
Function
Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.