TAF4B — TATA-box binding protein associated factor 4b
TAF4B belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TAF4B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Hypoxia metabolic stress Stress | ARG2, ARL4D, AXIN2, BNIP3, CITED4, CNKSR2, GCA, GSTM3 +13 more | View in SCUBA |
About the gene
| Synonyms | TAF2C2, TAFII105 |
|---|---|
| Chromosome | 18: 26226445-26391685 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Differentiation, Oogenesis, Spermatogenesis, Transcription, Transcription regulation |
Function
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF- kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.