P-TEFb Transcription Control
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 27 genes have a known function matching the annotation |
Why this annotation
The two highest-ranked hub genes, HEXIM1 and MEPCE, are the core components of the 7SK snRNP complex that sequesters and inhibits P-TEFb (CDK9/cyclin T), a master regulator of transcription elongation. This is a highly specific and coherent functional pair. Supporting genes include SOCS1 (cytokine signaling suppressor), GADD45B (stress/DNA damage response), IER5L (immediate early response gene), RASD1 (stress-induced RAS-like GTPase), CSRNP2 (transcription factor), MYCL (MYC-family), CDKN1C (p57, CDK inhibitor enriched in mat_colono). The module is specifically upregulated in CD inflammation and suppressed by CD treatment. The 7SK/P-TEFb axis is a known stress and inflammatory transcriptional checkpoint.
Genes
Most correlated modules
- Stress RNA Methylation · correlation 0.77
- Metabolic Homeostasis · correlation 0.65
- Transcriptional Golgi Remodeling · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.