CDKN1C — Cyclin dependent kinase inhibitor 1C
CDKN1C belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDKN1C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Pol II Transcription Regulation DNA/chromatin regulation | ABHD5, BAIAP2, BRD2, CBX4, CITED2, CKS2, EHD1, EIF4A1 +28 more | View in SCUBA |
| Glial cells | Glial Quiescence State Development | AATK, FADS3, PPP1R10, RGCC, RSRP1, SLC38A2, SOX2, SRSF5 | View in SCUBA |
| Monocytes | Non-classical Monocyte Innate immunity | CD79B, CDH23, CHST7, CKB, CYFIP2, KNDC1, LYPD2, NEURL1 +6 more | View in SCUBA |
| Smooth muscle cells | SMC Ion Signaling Contractility | ANTXR2, ATP1B1, CENPW, FAM83D, FXYD6, GAS1, KCNMA1, LRIG1 +12 more | View in SCUBA |
About the gene
| Synonyms | BWCR, BWS, KIP2, P57 |
|---|---|
| Chromosome | 11: 2883213-2885775 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Protein kinase inhibitor |
| Biological process | Cell cycle |
Function
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.