CSKMT — Citrate synthase lysine methyltransferase
CSKMT belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSKMT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Metabolic reprogramming Housekeeping | ATG16L2, ATP1A1, CCNYL1, EIF1AY, FAM241A, HMGCS1, ING1, KLF10 +12 more | View in SCUBA |
| Fibroblasts | Hypoxia-driven EMT Stress | ARC, CITED2, DDIT4, FAM43A, FAM53C, HBEGF, HEXIM1, IER5L +7 more | View in SCUBA |
| Gamma-delta T cells | AP-1 Immediate Early Response Stress | BRD2, CITED2, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B, HEXIM1 +25 more | |
| Mucosal-associated invariant T cell | AP-1 Immediate Early Stress | AMD1, BRD2, CITED2, FUS, GADD45B, GADD45G, H2AX, HEXIM1 +17 more |
About the gene
| Synonyms | CS-KMT, METTL12, U99HG |
|---|---|
| Chromosome | 11: 62665309-62668496 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.