ADRB2 — Adrenoceptor beta 2
ADRB2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADRB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2, ITGA1 +13 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Tissue Egress migration & adhesion | ANTXR2, C1orf162, KLRG1, NSG1, RASSF3, RIPOR2, S1PR1, SAMD3 +7 more | |
| Natural Killer cells | Innate Sensing NK Regulation Immune regulation | DTHD1, FCRL6, LFNG, LIMD2, PLEK, PRR5L, PYHIN1, UBE2F +1 more | View in SCUBA |
About the gene
| Synonyms | ADRB2R, ADRBR, B2AR, BAR |
|---|---|
| Chromosome | 5: 148826611-148828623 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.