THEMIS — Thymocyte selection associated
THEMIS belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
THEMIS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell co-receptors T cell development | AGO4, ARRB2, CAPG, CD200R1, CD40LG, CD96, EMB, FKBP11 +13 more | View in SCUBA |
| Gamma-delta T cells | RNA Splicing Nuclear RNA processing & translation | ATRAID, BABAM2, C7orf50, CIB1, CSNK2A1, FUNDC2, GOLGA8A, GOLGA8B +10 more | |
| Mucosal-associated invariant T cell | T cell Homeostasis T cell maturation | DNAJB14, EPS15, GLG1, INPP5D, MGA, OSBPL3, PHC3, PRP4K +3 more |
About the gene
| Synonyms | bA325O24.3, bA325O24.4, C6orf190, C6orf207, FLJ40584, TSEPA |
|---|---|
| Chromosome | 6: 127708072-127918631 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Adaptive immunity, Immunity |
Function
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.