RNA Splicing Nuclear
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes include GTF2IRD2B (transcription factor, TFII-I related), MATR3 (matrin-3, nuclear matrix RNA-binding protein), GOLGA8B/GOLGA8A (golgins, Golgi structural maintenance), PRRC2B (RNA-binding protein), SNRPB2 (U2 snRNP splicing factor), U2AF1 (U2 auxiliary factor splicing), TAF11 (TFIID subunit, transcription). The module has moderate coherence and combines nuclear RNA processing/splicing (MATR3, SNRPB2, U2AF1, PRRC2B) with Golgi structural components (GOLGA8A/B) and transcription regulators. The RNA splicing/nuclear matrix program is most coherent among hub genes.
Genes
ATRAID, BABAM2, C7orf50, CIB1, CSNK2A1, FUNDC2, GOLGA8A, GOLGA8B, GTF2IRD2B, MATR3, MRPL33, PRRC2B, SMIM27, SNRPB2, SPEF2, TAF11, THEMIS, U2AF1, UBE2D2
Most correlated modules
- Metabolic Housekeeping · correlation 0.81
- DNA Damage Repair · correlation 0.77
- Mitochondrial Biogenesis · correlation 0.76
- ATP Synthase Complex · correlation 0.73
- RNA Processing · correlation 0.72
- Ubiquitin-Proteasome Trafficking · correlation 0.72
- Mitochondrial Ribosome · correlation 0.71
- Actin-based Motility · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.