PHC3 — Polyhomeotic homolog 3
PHC3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACIN1, ASH1L, BDP1, BLTP1, CLTC, EPS15, EXOC2, FAM120B +24 more | |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Homeostasis T cell maturation | DNAJB14, EPS15, GLG1, INPP5D, MGA, OSBPL3, PRP4K, SETX +3 more | |
| Neutrophils | Apoptotic Neutrophil Program Developmental | ANO10, APAF1, ARFGEF1, ATF7IP, BLTP1, CEP350, FAR2, FBXW2 +5 more |
About the gene
| Synonyms | EDR3, FLJ12729, FLJ12967, HPH3 |
|---|---|
| Chromosome | 3: 170086732-170181749 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein, DNA-binding |
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.