OSBPL3 — Oxysterol binding protein like 3
OSBPL3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OSBPL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Post-transcriptional RNA Regulation RNA processing & translation | CCNG1, DHX15, FUBP1, HNRNPA3, IPO7, ITPR2, PLEKHB2, SP140 | |
| Hematopoietic progenitor cells | Lymphoid Progenitor Commitment Lymphcyte development | BASP1, CCR9, LRRC38, LSAMP, LZTFL1, MME, SCN3A, SH3BP5 +3 more | |
| Macrophages | MITF Lysosomal Program Lysosomal & pahgocytosis | ABHD3, ANKRD44, ARSB, C2CD5, CERS6, CHST11, CNST, DCTN4 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Homeostasis T cell maturation | DNAJB14, EPS15, GLG1, INPP5D, MGA, PHC3, PRP4K, SETX +3 more |
About the gene
| Synonyms | KIAA0704, ORP-3, ORP3, OSBP3 |
|---|---|
| Chromosome | 7: 24796540-24981634 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.