ATRAID — All-trans retinoic acid induced differentiation factor
ATRAID belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATRAID's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Lysosomal Biogenesis Vesicular traficking | APP, CPQ, CST3, GLG1, GRN, HEXA, LGALS3BP, NDN +5 more | View in SCUBA |
| Gamma-delta T cells | RNA Splicing Nuclear RNA processing & translation | BABAM2, C7orf50, CIB1, CSNK2A1, FUNDC2, GOLGA8A, GOLGA8B, GTF2IRD2B +10 more | |
| Lymphatic endothelial | Fatty Acid Oxidation Lipid metabolism | ECH1, ECHS1, ETFB, FCGRT, NDUFB10, PEBP1, PRDX2, TMEM14C | View in SCUBA |
| Macrophages | Glycolytic Metabolism Housekeeping | ARL1, ARPC5, ATP5PB, C4orf3, CALM1, CAPZA2, CHMP5, CIAO2A +30 more | View in SCUBA |
About the gene
| Synonyms | APR3, C2orf28, HSPC013, p18 |
|---|---|
| Chromosome | 2: 27212041-27217178 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Differentiation |
Function
Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.