T cell Homeostasis
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub gene INPP5D (SHIP1) is a central phosphoinositide phosphatase regulating PI3K/Akt signaling in lymphocytes. THEMIS is a T cell maturation/signaling protein. PHC3 is Polycomb group, involved in chromatin repression. MGA antagonizes MYC. SETX resolves R-loops at transcription-replication conflicts. PRP4K regulates splicing. TUT7 uridylates RNA for degradation. OSBPL3 is a lipid transfer protein. GLG1 is Golgi-resident. EPS15 mediates endocytosis. SLC16A7 is a monocarboxylate transporter. Together the module reflects broad homeostatic regulation: PI3K dampening (INPP5D), T cell identity (THEMIS), chromatin silencing (PHC3, MGA), and RNA/protein quality control. Uniform expression across subsets suggests a constitutive T cell homeostatic program rather than a reactive one.
Genes
DNAJB14, EPS15, GLG1, INPP5D, MGA, OSBPL3, PHC3, PRP4K, SETX, SLC16A7, THEMIS, TUT7
Most correlated modules
- Lymphocyte Migration · correlation 0.84
- SWI/SNF Chromatin Remodeling · correlation 0.84
- Nuclear regulatory housekeeping · correlation 0.82
- Circadian Transcriptional Regulation · correlation 0.81
- Immune Synapse Signaling · correlation 0.80
- Cellular Maintenance · correlation 0.79
- RAS-GEF Signaling · correlation 0.78
- TCR Activation Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.