TMEM63C — Transmembrane protein 63C
TMEM63C belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM63C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | BEST4 Colonocyte Identity Epithelial development | ADRA2A, AOAH, CCNJL, CDC14A, CENPJ, CNTFR, EEF2K, EXD3 +25 more | View in SCUBA |
About the gene
| Synonyms | C14orf171, CSC1, DKFZp434P0111, hsCSC1 |
|---|---|
| Chromosome | 14: 77116568-77259495 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Ion channel |
| Biological process | Ion transport, Transport |
Function
Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress. In contrast to TMEM63B, does not show phospholipid scramblase activity. Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes. In particular may regulate mitochondrial motility and function in motor neuron axons. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.