TNFRSF13B — TNF receptor superfamily member 13B
TNFRSF13B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF13B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation B cell maturation | CCDC50, IL10RA, NCR3, PTPN12, RBM47, RORA, SAMSN1, TBC1D9 +4 more | View in SCUBA |
| CD4⁺ T cells | IL10/cytokine signaling Immune regulation | CASK, CCDC141, FOXN3, IL10RA, IL7, SLC12A6, STAMBPL1, TMEM154 +4 more | View in SCUBA |
About the gene
| Synonyms | CD267, IGAD2, TACI |
|---|---|
| Chromosome | 17: 16929816-16972118 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity |
Function
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin- dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.