NCR3 — Natural cytotoxicity triggering receptor 3
NCR3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation B cell maturation | CCDC50, IL10RA, PTPN12, RBM47, RORA, SAMSN1, TBC1D9, TCF4 +4 more | View in SCUBA |
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAP1, ALOX5AP, AOAH, CD244, CMIP, CPNE7, CRTAM, DAPK2 +15 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Actin Motility Cytoskeleton & motility | ACAP1, ARHGDIB, CORO1A, DGCR6L, EVL, GPSM3, HEXA, LCK +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Antigen Processing Protein processing & ER | AQP3, ATP5MJ, CAPNS1, CCDC107, CTDNEP1, NSA2, PHB2, PPA1 +8 more | |
| Natural Killer cells | NK Homing Adhesion Homing & TEM | CHST2, IGFBP7, ITGAM, LAIR1, MLC1, MYOM2, SPN | View in SCUBA |
About the gene
| Synonyms | 1C7, CD337, LY117, NKp30 |
|---|---|
| Chromosome | 6: 31588895-31593006 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Immunity |
Function
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.