B cell activation
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include TNFRSF13B (TACI), a key B cell receptor for BAFF/APRIL regulating B cell maturation and isotype switching; TCF4 (E2-2), a transcription factor in B/pDC development; RORA, CCDC50 (NF-kB modulator), SAMSN1 (B cell signaling adaptor), and IL10RA. The combination of TNFRSF13B, TCF4, SAMSN1, RBM47 reflects B cell activation/maturation programs rather than a discrete artifact. Coherence is core and expression is uniform across subsets, consistent with a B-cell intrinsic maturation program. The UC inflammation association supports an activated/mature B cell state.
Genes
CCDC50, IL10RA, NCR3, PTPN12, RBM47, RORA, SAMSN1, TBC1D9, TCF4, TFEC, TMEM273, TMEM65, TNFRSF13B
Most correlated modules
- Lysosomal proteases · correlation 0.81
- Activated B cell · correlation 0.78
- Activation/Migration · correlation 0.76
- Interferon Response · correlation 0.76
- TNF/NF-kB response · correlation 0.76
- Leukocyte Migration Signaling · correlation 0.73
- Tissue-resident memory B · correlation 0.71
- BCR Signaling Regulation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.