SAMSN1 — SAM domain, SH3 domain and nuclear localization signals 1

SAMSN1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SAMSN1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B cell activation B cell maturation	CCDC50, IL10RA, NCR3, PTPN12, RBM47, RORA, TBC1D9, TCF4 +4 more	View in SCUBA
CD4⁺ T cells	Chemokine Migration migration & adhesion	CCR6, CYTIP, DDX24, FRMD4B, G3BP2, GNG2, GPBP1, KMT2E +7 more	View in SCUBA
CD8⁺ T cells	Cytotoxic Exhausted CD8 Exhaustion	CCL3, CD2BP2, CLEC2D, CTSD, DUSP4, GZMB, NDFIP2, PHLDA1 +2 more	View in SCUBA
Gamma-delta T cells	Hypoxia Tissue Adaptation Tissue residence	ABCB1, ADAMTS17, ANKRD28, CCRL2, EPAS1, FAM3C, KLHL6, LDLRAD4 +10 more
Innate lymphoid cells	NK ILC Tissue Homing Homing & TEM	ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107 +25 more	View in SCUBA
Macrophages	NF-κB AP-1 Signaling Inflammatory	ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more	View in SCUBA
Monocytes	NLRP3 Inflammasome Activation Innate immunity	ACSL1, BASP1, CCDC71L, CCL20, EREG, F3, FAM107B, LRG1 +3 more	View in SCUBA
Natural Killer cells	NK Immune Checkpoint Immune regulation	AKAP13, CHD1, G3BP2, LIMS1, MORF4L2, P2RY10, PTPN22, RANBP2 +1 more	View in SCUBA
Neutrophils	C5aR Complement Activation Innate immunity	ADGRG3, C5AR1, CD55, ITPRIP, LAPTM5, MCL1, PFKFB3, PTPRE +3 more

About the gene

Synonyms	HACS1, NASH1, SASH2, SH3D6B, SLy2
Chromosome	21: 14485228-14658821
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins

Function

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.