PTPN12 — Protein tyrosine phosphatase non-receptor type 12
PTPN12 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPN12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation B cell maturation | CCDC50, IL10RA, NCR3, RBM47, RORA, SAMSN1, TBC1D9, TCF4 +4 more | View in SCUBA |
| Endothelial | Endocytic Membrane Remodeling migration & adhesion | ARHGAP23, BNIP2, CDK17, EIF4G2, HERC1, KCTD15, LPCAT1, LRRC8A +4 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ABCA1, ACSL1, ALDH1A2, CRK, INPP5A, LIMK2, NUP98, PIK3R5 +6 more | |
| Pericytes | RAS Cytoskeletal Signaling Cytoskeletal | ARPC5L, CNDP2, FAM177A1, KLF3, KRAS, LRRFIP1, PEA15, UBE2J1 | View in SCUBA |
About the gene
| Synonyms | PTP-PEST, PTPG1 |
|---|---|
| Chromosome | 7: 77537295-77640069 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.