IL10RA — Interleukin 10 receptor subunit alpha
IL10RA belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL10RA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation B cell maturation | CCDC50, NCR3, PTPN12, RBM47, RORA, SAMSN1, TBC1D9, TCF4 +4 more | View in SCUBA |
| CD4⁺ T cells | IL10/cytokine signaling Immune regulation | CASK, CCDC141, FOXN3, IL7, SLC12A6, STAMBPL1, TMEM154, TNFRSF13B +4 more | View in SCUBA |
| Macrophages | Anti-inflammatory Response Inflammatory | AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Activation Signaling TCR Signaling | AGAP2, ARHGAP45, CDK5RAP3, DNMT1, ITGAL, JADE2, NBR1, PLCB2 +6 more |
About the gene
| Synonyms | CD210, CD210a, CDW210A, HIL-10R, IL10R |
|---|---|
| Chromosome | 11: 117986370-118003037 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
Function
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.