TOP1MT — DNA topoisomerase I mitochondrial
TOP1MT belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TOP1MT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | MET Tissue Repair Tissue homeostasis | BIN1, CXXC5, EMP2, EVA1C, JRK, MET, MPRIP, NTSR1 +3 more | View in SCUBA |
About the gene
| Chromosome | 8: 143304384-143359979 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Predicted intracellular proteins |
| Molecular function | DNA-binding, Isomerase, Topoisomerase |
Function
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.