BIN1 — Bridging integrator 1
BIN1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Leukocyte adhesion signaling migration & adhesion | ARHGDIB, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B, GYPC +22 more | View in SCUBA |
| Hematopoietic progenitor cells | Quiescent HSC State Stemness | ARHGEF17, BAALC, CD52, GNAI1, HOPX, MZB1, RBPMS, SPINK2 | |
| Monocytes | MET Tissue Repair Tissue homeostasis | CXXC5, EMP2, EVA1C, JRK, MET, MPRIP, NTSR1, RHPN1 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Trafficking migration & adhesion | AASDHPPT, ANXA2, ARL14EP, ATP2A3, BTN3A2, DGKZ, OSTC, PTP4A2 +8 more | |
| Natural Killer cells | Gut-Homing NK Maturation Gut residency | ANXA2, DHRS7, HECA, IFI27L2, ITGB7, KLF9, LGALS1, NDUFB7 +5 more | View in SCUBA |
About the gene
| Synonyms | AMPH2, AMPHL, SH3P9 |
|---|---|
| Chromosome | 2: 127048027-127107288 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Endocytosis, Host-virus interaction |
Function
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.