MPRIP — Myosin phosphatase Rho interacting protein
MPRIP belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MPRIP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 effector Th17 fate | CD6, CLSTN3, CTDSP1, IL17A, ITPRIPL2, MAP3K4, NFIL3, NMRK1 +6 more | View in SCUBA |
| Endothelial | Actomyosin Contractility Cytoskeletal | BCAP29, CAPN2, GNB2, INPP5A, ITPRIPL2, LGALS1, LRRC8C, NID1 +2 more | View in SCUBA |
| Fibroblasts | Focal Adhesion ECM Migration & adhesion | ACTN1, CLIC4, COL4A1, COL4A2, MRPL33, MYL6, NDUFA4, PARVA +6 more | View in SCUBA |
| Gamma-delta T cells | Nuclear Pore Organization Housekeeping | AIDA, DHX8, H4C6, LARP1, LBR, MTR, NNT, NUP155 +14 more | |
| Glial cells | TGF-beta Response Inflammation | BGN, CCDC85B, DPP7, KCND3, MEF2C, PMEPA1, TMEM59L, TMSB4X +1 more | View in SCUBA |
| Monocytes | MET Tissue Repair Tissue homeostasis | BIN1, CXXC5, EMP2, EVA1C, JRK, MET, NTSR1, RHPN1 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | EFCAB14, IQGAP1, LNPEP, MACF1, OGA, PHF3, PTBP3, RNF213 +4 more |
About the gene
| Synonyms | M-RIP, p116Rip, RHOIP3 |
|---|---|
| Chromosome | 17: 17042457-17217679 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin- binding region leads to disassembly of stress fibers in neuronal cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.