MET Tissue Repair
Gene co-expression module in Monocytes
| Category | Tissue homeostasis |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include MET (HGF receptor driving tissue repair and anti-inflammatory signaling in monocytes), NTSR1 (anti-inflammatory GPCR), CXXC5 (Wnt pathway modulator), RHPN1 and MPRIP (Rho GTPase/cytoskeletal regulators), and EMP2 (integrin-associated membrane protein). The module is downregulated in remission (UC and CD), suggesting it is active during intestinal inflammation and reflects a monocyte tissue repair/remodeling program. BIN1 contributes to endosomal/membrane remodeling. Together these genes represent MET-driven repair signaling with cytoskeletal and Wnt co-regulation.
Genes
BIN1, CXXC5, EMP2, EVA1C, JRK, MET, MPRIP, NTSR1, RHPN1, SMOX, TOP1MT, ZNF395
Most correlated modules
- Innate Immune Transcription · correlation 0.87
- Endosomal Sorting · correlation 0.84
- Secretory Vesicle Trafficking · correlation 0.82
- Inflammatory Autophagy · correlation 0.75
- AMPK-FOXO Stress Response · correlation 0.72
- Myeloid Epigenetic Regulation · correlation 0.71
- Autophagy Initiation · correlation 0.69
- Glucocorticoid Transcription · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.