TRIP10 — Thyroid hormone receptor interactor 10
TRIP10 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIP10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Inflammatory Cell Death Inflammatory | ARL4C, BTG3, CD63, HIC1, MFSD2A, NINJ1, PID1, SNN | View in SCUBA |
About the gene
| Synonyms | CIP4, HSTP, STOT, STP |
|---|---|
| Chromosome | 19: 6737925-6751530 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Endocytosis |
Function
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5- bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte- derived cells. May be required for the lysosomal retention of FASLG/FASL.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.