HIC1 — HIC ZBTB transcriptional repressor 1

HIC1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HIC1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Oxidative/ER stress Stress	ASAH1, ATP6V0D1, B4GALT1, FAM210A, FOSL2, GEM, GZF1, MAFG +6 more	View in SCUBA
CD4⁺ T cells	Cytotoxic Effector CD4 Cytotoxicity	ADAM8, ADRB2, CCL5, CHD9, DPP4, HOPX, IFIT2, ITGA1 +13 more	View in SCUBA
Endothelial	Inflammatory EC Activation Inflammation	ANGPT2, B3GNT5, BAIAP2, EPHA2, GMFB, HMOX1, JUP, LPIN2 +6 more	View in SCUBA
Gamma-delta T cells	Activation Stress Response Stress	ARHGAP9, ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HMCES, HMGCR +12 more
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1 +12 more	View in SCUBA
Lymphatic endothelial	Lymphatic Vascular Stability endothelial development	GJA1, GLT8D2, HSD17B12, IGFBP4, KCTD12, MAF, ROBO4, S1PR1 +6 more	View in SCUBA
Macrophages	MMP-driven ECM Remodeling ECM remodeling	A4GALT, ACP5, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX +12 more	View in SCUBA
Monocytes	Inflammatory Cell Death Inflammatory	ARL4C, BTG3, CD63, MFSD2A, NINJ1, PID1, SNN, TRIP10	View in SCUBA
Mucosal-associated invariant T cell	Tc17 / MAIT17 Tc17 program	AHR, BAIAP2, CA10, CCR9, GFPT2, IL17A, IL2, ITGA1 +5 more

About the gene

Synonyms	ZBTB29, ZNF901
Chromosome	17: 2054154-2063241
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation, Wnt signaling pathway

Function

Transcriptional repressor. Recognizes and binds to the consensus sequence '5- [CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down- regulation of SIRT1 and thereby is involved in regulation of p53/TP53- dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription of ACKR3, FGFBP1 and EFNA1.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.