Inflammatory Cell Death
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
NINJ1 (nerve injury-induced protein 1) is a cell surface protein recently identified as a critical mediator of plasma membrane rupture during inflammatory cell death (pyroptosis, necroptosis, NETosis). SNN (stannin) promotes apoptosis. BTG3 is an anti-proliferative/pro-apoptotic gene. PID1 modulates insulin/PI3K signaling and is linked to cell survival. CD63 is a lysosomal tetraspanin upregulated during monocyte activation and vesicle secretion. MFSD2A is a fatty acid transporter. HIC1 is a transcriptional repressor linked to stress responses. TRIP10 (CIP4) regulates actin dynamics and membrane trafficking. ARL4C regulates cytoskeletal organization. The module is moderately coherent and upregulated in IBD inflammation, particularly CD. The NINJ1/SNN/BTG3 axis suggests inflammatory cell death programs in activated monocytes.
Genes
ARL4C, BTG3, CD63, HIC1, MFSD2A, NINJ1, PID1, SNN, TRIP10
Most correlated modules
- NF-κB Signaling · correlation 0.71
- Monocyte Immune Tolerance · correlation 0.67
- Epigenetic Inflammatory Reprogramming · correlation 0.67
- Monocyte Tissue Infiltration · correlation 0.65
- Integrin-mediated Migration · correlation 0.63
- Monocyte-Macrophage Differentiation · correlation 0.63
- G-protein Membrane Remodeling · correlation 0.62
- Tissue-destructive Macrophage · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.