MFSD2A — Major facilitator superfamily domain containing 2A
MFSD2A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MFSD2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | ER-autophagy homeostasis Protein processing & ER | AQP11, CCSER2, CTSD, PLOD2, RB1CC1, REEP3, RESF1, SMPDL3A +1 more | View in SCUBA |
| Monocytes | Inflammatory Cell Death Inflammatory | ARL4C, BTG3, CD63, HIC1, NINJ1, PID1, SNN, TRIP10 | View in SCUBA |
About the gene
| Synonyms | FLJ14490, MFSD2, SLC59A1 |
|---|---|
| Chromosome | 1: 39955112-39969968 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Biological process | Lipid transport, Symport, Transport |
Function
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.