TUBB2B — Tubulin beta 2B class IIb
TUBB2B belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TUBB2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Cytoskeletal Glial Homeostasis Cytoskeletal | ABCA1, ANKRD12, ATP1B1, FERMT2, PHLDB1, PRKCA, TUBA1A, TUBA1B +1 more | View in SCUBA |
About the gene
| Synonyms | bA506K6.1, DKFZp566F223, MGC8685 |
|---|---|
| Chromosome | 6: 3223324-3231730 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Neurogenesis |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.