Cytoskeletal Glial Homeostasis
Gene co-expression module in Glial cells
| Category | Cytoskeletal |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include ANKRD12 (ankyrin repeat, scaffold), ATP1B1 (Na/K-ATPase beta-1, ion transport, glial homeostasis), PRKCA (protein kinase C alpha, signaling), TUBA1B and TUBA1A (alpha-tubulins, cytoskeleton), TUBB2B (beta-tubulin), WSB1 (WD repeat/SOCS-box protein, ubiquitin ligase adaptor, HIF regulation), FERMT2 (kindlin-2, integrin activation/adhesion), PHLDB1 (pleckstrin homology domain, PI3K signaling), ABCA1 (lipid efflux transporter). Module coherence is moderate, and two tubulin genes (TUBA1A, TUBA1B, TUBB2B) suggest some cytoskeletal component. PRKCA and ATP1B1 suggest glial signaling and ion homeostasis. FERMT2 ties in adhesion. Downregulated in inflammation, suggesting homeostatic glial program. The tubulin genes and PRKCA together with FERMT2 suggest a cytoskeletal and adhesion-related glial state. Given the neighborhood (M48, M21, M69 all glial homeostatic), this module likely represents a cytoskeletal/adhesion component of glial homeostasis.
Genes
ABCA1, ANKRD12, ATP1B1, FERMT2, PHLDB1, PRKCA, TUBA1A, TUBA1B, TUBB2B, WSB1
Most correlated modules
- Glial Synaptic Adhesion · correlation 0.80
- ECM Homeostatic Regulation · correlation 0.76
- Glial Homeostatic Identity · correlation 0.75
- Glial Cytoskeletal Homeostasis · correlation 0.72
- Neuroprotective Secretory · correlation 0.69
- Glial Quiescence State · correlation 0.66
- Neural Migration Scaffold · correlation 0.66
- Myelinating Schwann Cell · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.