ABCA1 — ATP binding cassette subfamily A member 1
ABCA1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Interferon Response Inflammatory | A4GALT, ABHD17C, BASP1, CCL7, CLEC2B, IFI16, IFI6, PLSCR1 +5 more | View in SCUBA |
| Glial cells | Cytoskeletal Glial Homeostasis Cytoskeletal | ANKRD12, ATP1B1, FERMT2, PHLDB1, PRKCA, TUBA1A, TUBA1B, TUBB2B +1 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome Regulation Housekeeping | AVL9, EHMT1, GIGYF2, HUWE1, LCORL, PAXBP1, PPP2R2D, PPP2R5C +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-beta Response Immune regulation | ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1, HYPK +21 more | |
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ACSL1, ALDH1A2, CRK, INPP5A, LIMK2, NUP98, PIK3R5, PTPN12 +6 more |
About the gene
| Synonyms | ABC1, HDLDT1, TGD |
|---|---|
| Chromosome | 9: 104781006-104928155 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport |
Function
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.