FERMT2 — FERM domain containing kindlin 2

FERMT2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FERMT2's module in each cell type

Cell type	Module	Shares the module with
Fibroblasts	Actin-Integrin Adhesion Migration & adhesion	ACTR2, ACTR3, C5orf24, CAP1, CD151, DEGS1, GNB1, ITGB1 +5 more	View in SCUBA
Glial cells	Cytoskeletal Glial Homeostasis Cytoskeletal	ABCA1, ANKRD12, ATP1B1, PHLDB1, PRKCA, TUBA1A, TUBA1B, TUBB2B +1 more	View in SCUBA
Smooth muscle cells	Integrin adhesion complex Migration & adhesion	ALDH1B1, ALDH2, DST, ITGA5, KLHL42, METTL7A, NFIX, NPTN +3 more	View in SCUBA

About the gene

Synonyms	KIND2, mig-2, PLEKHC1, UNC112B
Chromosome	14: 52857268-52952435
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Cell adhesion, Cell shape, Wnt signaling pathway

Function

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.