TUBA1B — Tubulin alpha 1b

TUBA1B belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TUBA1B's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Pol II Transcription Regulation DNA/chromatin regulation	ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more	View in SCUBA
CD8⁺ T cells	Mitotic Spindle Cell cycle	ASF1B, CENPN, DDX39A, DTYMK, GGH, HMGB2, HMGN2, LMNB1 +3 more	View in SCUBA
Gamma-delta T cells	G1/S Entry Cell cycle	CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2 +15 more
Glial cells	Cytoskeletal Glial Homeostasis Cytoskeletal	ABCA1, ANKRD12, ATP1B1, FERMT2, PHLDB1, PRKCA, TUBA1A, TUBB2B +1 more	View in SCUBA
Goblet cells	S/G2 Preparation Cell cycle	DTYMK, EXOSC8, HMGN2, LMNB1, LSM3, LSM5, MIS18A, MIS18BP1 +4 more	View in SCUBA
Innate lymphoid cells	Dissociation Stress Response Stress	C12orf57, CA2, CALM2, EHD1, EIF4A2, IER2, MEPCE, NDRG1 +9 more	View in SCUBA
Lymphatic endothelial	Translation Elongation RNA processing & translation	ANXA2, EEF1A1, EEF2, EIF1, FTH1, FTL, HNRNPA0, HNRNPA1 +2 more	View in SCUBA
Macrophages	Mitochondrial OXPHOS Mitochondrial & OxPhos	ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, HIGD2A, LAMTOR4 +9 more	View in SCUBA
Monocytes	Non-classical Monocyte State Tissue adaptation	CAMK1D, CTSC, FAM162A, MS4A7, NBDY, SLC25A33, SLC3A2, TUBB	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more
Natural Killer cells	G2/M Transition Cell cycle	ANP32B, CARHSP1, NSD2, PHF19, SMC2, STMN1, TMPO, TUBB	View in SCUBA
Neutrophils	Mitotic Spindle Cell cycle	ANP32B, ANP32E, DEK, H2AZ2, H4C3, HMGB1, HNRNPH1, HP1BP3 +4 more
Smooth muscle cells	Proliferative Biosynthesis Housekeeping	ARF5, BUB3, CBX5, DCTN3, DUT, HMGN2, IDH2, KRTCAP2 +7 more	View in SCUBA

About the gene

Synonyms	K-ALPHA-1
Chromosome	12: 49127782-49131397
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Molecular function	Hydrolase

Function

Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.