TWNK — Twinkle mtDNA helicase
TWNK belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TWNK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | DNA Damage Response Stress | ACSL4, AKNA, ALDH4A1, ATF7IP, ATM, BAIAP2, BCL11B, BCL9 +22 more | View in SCUBA |
About the gene
| Synonyms | C10orf2, FLJ21832, IOSCA, PEO, PEO1, TWINKLE, TWINL |
|---|---|
| Chromosome | 10: 100987367-100994403 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, Isomerase |
| Biological process | DNA replication |
Function
Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand. In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities. Lack DNA unwinding and ATP hydrolysis activities. Does not bind single-stranded or double-stranded DNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.