UBAC1 — UBA domain containing 1
UBAC1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBAC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Complex I / NADH Dehydrogenase Mitochondrial & OxPhos | AHCY, ANP32A, ANTKMT, APEX1, ARL2, ATIC, ATP5F1A, ATP5ME +31 more | View in SCUBA |
About the gene
| Synonyms | GBDR1, KPC2, UBADC1 |
|---|---|
| Chromosome | 9: 135932969-135961373 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Non-catalytic component of the KPC complex, a E3 ubiquitin- protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor. Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.